Back when I was still using macOS I loved Little Snitch and was a paying customer. And I agree nothing on Linux comes close. Would it be technically feasible to also provide this as a Flatpak to support immutable distros like Bazzite?
As far as I can tell, Flatpak does not allow a daemon running as root early during system boot.
I’m not aware of flatpaks specifically having th capability to run system software, daemons, etc. Some other immutable packaging formats should be able to (systemd-sysext at least, and snap iirc).