Several of the top Chrome extensions on their charts are ad blockers: https://chromewebstore.google.com/top-charts/popular?hl=en

They have an API basically dedicated to this: https://developer.chrome.com/docs/extensions/reference/api/d...

I think you may have been confused about the Manifest V3 API changes, which were controversial because they didn't support every feature of the old API. The mainstream ad blockers all wrote new versions for Manifest V3.