alt Hacker News>These are industrial experiments, in a similar vein to various Canola oils but much worse.
Ah, a "seed oil" guy. This is the indication to everyone what level of discourse and scientific fact you're bringing to the table.
In fact, I'll just cite one single bit in your claim-
>Contrary to their purpose, some studies show artificial sweeteners may raise type 2 diabetes risk by up to 38%
This suffers from the same "aha!" nonsense as the garbage submission (and it is garbage). The "study" you are citing was an observational, epidemiological study. And wow, crazy and hard to believe, but it turns out that people with weight problems (and all that comes with that) are more likely to have partaken of "at least one" sugar substitute drink. This is similar to studying people who chew nicotine gum and for obvious reasons finding a higher rate of lung cancer, so then declare that nicotine gum causes lung cancer. It is so staggeringly stupid it belies belief, but it makes for a headline to fool some rubes.
Just for everyone to make up their own minds based on the data, here are multiple studies:
2025: https://www.sciencedirect.com/science/article/pii/S126236362...
2023: https://pmc.ncbi.nlm.nih.gov/articles/PMC10465821/
To address your point: Potential for reverse causality cannot be eliminated; however, many sensitivity analyses were computed to limit this and other potential biases
2023: Clinical review https://pmc.ncbi.nlm.nih.gov/articles/PMC10822749/
multiple studies have shown various side effects associated with the use of these sweeteners. These side effects include gastrointestinal symptoms [9], neurologic [10] and taste perception changes [11], allergic reactions [12], insulin and metabolic effects [13], and cardiovascular effects [14]. In addition, ASs have been shown to affect the gut microbiota that may mediate certain side effects [15]. Most importantly, many researchers have assessed the potential effect of ASs on the cancer risk of people who consume these products [16,17].
and
Human studies performed by Suez et al. evaluated the impact of ASs on the human microbiome. A total of 381 individuals without diabetes who self-reported regular consumption of ASs, as determined by a food frequency questionnaire, were included. The study demonstrated a significant association between the consumption of ASs and the development of central obesity, elevated fasting blood glucose levels, increased hemoglobin A1c levels, impaired glucose tolerance, and elevated alanine aminotransferase levels. In addition, a subgroup analysis was conducted to compare those who consumed higher amounts of ASs with those who did not consume any ASs. The results of this analysis revealed a statistically significant elevation in hemoglobin A1c levels, even after controlling for body mass index.