> If you want to get depressed about all the problems with trying to colonize Mars

I had the opposite reaction. I thought it set forward a realistic set of challenges we have to solve and experiments we have to do before building anything more than a research outpost on Mars. That, in turn, makes a permanent Moon base more valuable.

Standout problems were low- and zero-g trauma medicine, plumbing (something Artemis II started working on) and mammalian reproduction.