if you use nixos you end up feeling like you need to spend more time developing your personal computer's configuration than developing your actual projects, ime.

it kind of 'just works' if someone already wrote the nix code to do what you want it to do and put it in nixpkgs and you manage to find it and figure out how to use it. but if that isn't the case, good luck. i once spent almost a week trying to get a program to build and run properly under nix that could probably be installed in around 20 seconds on a osx/windows machine.