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epcoa • today at 4:52 AM • 2 replies • view on HN

No. Ethanol and tylenol compete for CYP2E1 that produces toxic NAPQI, so no, acute alcohol intoxication has a protective effect at least where it comes to tylenol toxicity.

Replies

robocat • today at 8:55 AM

No.

Alcohol and Acetominophen/paracetamol should not be mixed.

  When alcohol enters the picture, it increases the activity of CYP2E1, so the body produces more of the NAPQI toxin. Alcohol also decreases glutathione production, the body’s natural defense mechanism, meaning NAPQI is more likely to build up in the liver in dangerous concentrations.
https://www.medicalnewstoday.com/articles/322813

Sorry, crappy link. If you don't like it, it is easy to search for a better one.

Flashtoo • today at 7:56 AM

This is correct.