The Register source has this comment:

    // Registers can't be a record type because the values need to be truncated to 8 bits when writing, so setters are needed
    // This is for the web renderer as Fable transpiles uint8 to Number (more than 8 bits) in JS and doesn't apply any truncation
    // Known non-standard behaviour in Fable (https://fable.io/docs/javascript/compatibility.html#numeric-types)

So, I think, it's just conservatively cleaning the data due to Fable's widening via js Number on the web target.