Stretch or not, MDAC can no longer be installed on Windows. (The Microsoft Data Access Components are a rollup of database interface libraries from when they seemed to do around one a year, to the point that Spolsky remarked on it[1].) This means a significant corpus of old but still 32-bit line-of-business apps no longer runs, like anything written in VB6 or VBA that needs to access a database.

[1] https://www.joelonsoftware.com/2002/01/06/fire-and-motion/