Chrome on Windows is running with thousands of tabs "open" over dozens of windows, but it does practically max out on a certain number of tabs per window (not just the GUI, but something in the memory architecture), and it does stack fat cache which will crash the whole thing if it digs deeper than your available space.

Windows even runs (semi-playably) 2020's shooters in this condition, though you need to kill any windows close to the tab limit that are full of recently opened tabs.

[Yes, I know, the horror]