We will never draw the line because morality among humans is coupled with looking human-like. For most people, their morals have aesthetic prerequisites, neurons in a lab don't mean as much as neurons in a meat case (especially if that meat case is physically attractive)
And even "human-like" had some pretty strict definitions back in the day, and probably still now for some people. The people working the fields in the American South certainly weren't thought of as having the same "personhood" on any level as their owners.