No if you use GitHub Enterprise Cloud with data residency then you are on separate infrastructure. Here is the status page for the US enterprise cloud data residency https://us.githubstatus.com/posts/dashboard (which funny enough is reporting an issue atm).

You can tell if you are on the github enterprise with data residency because you will access github at a GHE.com domain rather than github.com. It definitely has better uptime than the public cloud but is not without its own issues.