As a former Latin instructor with literally decades of experience, I strongly recommend not relying solely on Ørberg. The outcomes of those who refused to supplement it with a proper grammar and dictionary were far, far behind those who used Wheelock alone.
It's very popular online, but it's methodologically bunk.
As a former pupil that took 7+years of Latin, I think the probability of actually reading latin texts fluently today would have been orders of magnitude higher had instruction been coupled with Ørberg. I still want to be able to read hobbitus ille, but no thanks to my Latin classes (and I think I had decent teachers).
I've only been on the student side of this (with Hebrew), but that has been my experience as well. These sorts of books can work, but it needs extraordinarily good teachers to do so.
Thanks for the perspective! I guess it depends on the outcomes in question
If they're measured by traditional academic metrics (parsing, recalling declension tables, translating into English), then Wheelock's grammar-first approach really does optimize for that. On the other hand Ørberg optimizes more for reading fluency and intuitive comprehension, which is harder to measure on a standard Latin exam.