As others have said, the main benefit with Python over Rust is library support especially with ML features. The other gap as I see it with Rust is the lack of native flexible UI support. The nice thing about Rust though is it can serve as a very fast and stable core for an app and offload specifics to TS and Python as their strengths allow, so you get the best of all worlds.

My current goto for desktop apps is Tauri, which give us a rust backend and TS fronted (usually React). Local ML features can be easily loaded as a python sidecar. Production bundling can be a little challenging but it seems to work well so far.

Sidenote: Golang is also an amazing language for LLM use, I generally do most of my "infra" stuff in Golang over Rust, but either work fine most of the time.