The simple answer is, I choose to use Python because I am productive with it. I get a lot done compared to the other languages I have tried. Performance is almost never the limiting factor in my work, nor has it been for the vast majority of the work I've ever been witness to. When it is, it comes up in very particular circumstances, and can usually be fixed algorithmically. Indeed, that is the situation where I have used profilers.
The fact that the base language is an order of magnitude (or two!) slower has almost never mattered. If my work gets to the point where it does, and I have an excuse to go mess around with a rust extension or some cool optimized library, things are going very well.
I've been professional developer for over 20 years now, and I've read this forum obsessively for much of that time. I've seen people write things like, "Most engineers would kill for a 5% speedup" and I think, on what planet? Most engineers have much larger problems that cannot be so easily quantified. Come to think of it, I think that there is an allure to performance optimization due to the fact that it can be so easily quantified.
> I choose to use Python because I am productive with it.
That, I fully understand. I think many developers are productive in one language: in the one that they know best. Which is probably the one they use most. It might happen that this is is a "fast" language by accident (like Java or Go), or a language like Python. And then there is never enough reason to switch.
> "Most engineers would kill for a 5% speedup"
I think this is very rare - maybe a heavily used app in Facebook or Google, where 5% could mean a lot of money. But a factor of 10 speedup is much more common (and possible sometimes).
> there is an allure to performance optimization due to the fact that it can be so easily quantified.
That's true. I also think simplicity is quantifiable, and so my personal hobby is to write something impressive in few lines. Like a chess engine, QR code reader, editor, data compression tool, compiler, in 500 lines. But this is mostly for hobbies I guess. For work, it's mostly about features, and then performance, I guess.