Respectfully, comparing a janitor's 401k to a $27.4 billion endowment is (very) tone deaf.
But yes, the tax goes against "keeping sacred systems sacred" principles and is an opinionated policy against rich entities that the current administration dislikes.
Yes, it's tone deaf. And comparing tax on an endowment to "tax a janitor pays" is arguing in bad faith.
US federal government taxation policy shouldn't treat university endowments as sacred systems.