two semi interesting things to note around this:

1. Virtualization.framework seems to support some form of GPU passthrough from the host (granted, not eGPU - it's for the integrated GPU). I think the primary use case is having macOS guests get acceleration, while still sharing GPU time with the host. There is also a patch that recently hit QEMU mainline that supports using the "venus server" with virtio-gpu to support a similar functionality for Linux guests under Hypervisor.framework.

2. Apple internally has some kind of PCI Passthrough support available in Virtualization.framework. It seems like the code is shipped to customers in the framework, but it relies on some kind of kext or kernel component that isn't shipped in retail macOS. I can't say if that's intended to ever be released to customers, but clearly someone at Apple has thought about this the feature.