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Aurornistoday at 2:15 PM1 replyview on HN

I think this is the clinical trial registration: https://clinicaltrials.gov/study/NCT03408886?tab=results

It is marked as having results submitted but quality review has not been completed.

N=60 and a placebo group, which is better than the N=18 and no placebo group of the first study.

There have been so many small scale trials showing amazing autism improvements that failed to replicate in larger, better controlled trials. I wouldn’t get excited yet.

The typical pattern is to show unbelievably good results in the first open-label trial with a small number of patients (their n=18 trial that claims to have cured severe autism in many children), squeak by with some marginal improvement in the next trial over placebo, then the third trial becomes a game of trying to keep the study small enough that they can hope to p-hack a result that the FDA might accept.


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cpncrunchtoday at 3:35 PM

Study completed in 2022, but still no results posted or study published.

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