If Tailwind lends itself to using pixels instead of relative units for things that should be relative (like font-size, line-height, etc.), that's a problem.
For those users, the HTML elements matter less unless they're savvy users who have custom user stylesheets to selectively adjust the appearance of content instead of changing everything on the page by zooming (e.g. make links, buttons, paragraphs, list items bigger and/or a different font or weight).
alt Hacker News
If Tailwind lends itself to using pixels instead of relative units for things that should be relative (like font-size, line-height, etc.), that's a problem. For those users, the HTML elements matter less unless they're savvy users who have custom user stylesheets to selectively adjust the appearance of content instead of changing everything on the page by zooming (e.g. make links, buttons, paragraphs, list items bigger and/or a different font or weight).