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dimestoday at 3:20 PM3 repliesview on HN

I’m not going to pretend to be an expert here, but I remember a study that found gut bacteria composition predicted whether or not an individual was chocolate-craving or not in individuals eating identical diets: https://pubmed.ncbi.nlm.nih.gov/17929959


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dathinabtoday at 6:03 PM

putting aside what others have commented about the truastability of studies and similar

- what all studies show is some vague "craving" for something generic, e.g. the link between iron deficiency and craving for ice

- but what you see in autists is often a far stronger effect and not just for eating something, but also against eating most other food. A craving for chocolate does not remove appetite and willingness to eat other food. It just makes you really want to eat chocolate.

- more important the way autistic people get fixated on a monotonous diet is far more specific then any effects we have observed from gut bacteria or other similar sources AFIK. Like lets say your gut bacteria might make you crave fish. You autism on the other hand might make you crave dino formed fish sticks with a specific texture. And there is just no way gut bacteria care about your fish sticks being dino formed or the specific texture of them... But a autistic person often does care, quite a bit even.

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Aurornistoday at 3:55 PM

You have to be careful with microbiome research because it’s a buzzword that gets crammed into a lot of research papers to imply something bigger. This is a single paper from Nestle Research Center (yes that Nestle) from 2007 that doesn’t even cite a number of people sampled in the abstract.

They didn’t run any experiments trying to change the diet or microbiome. They just correlated dietary preferences with some markers that might be correlated with the microbiome.

The paper does not say anything about how changing the microbiome might change preferences. The simplest and most well tested explanation is that dietary preference are driving the microbiome.

There’s a lot of woo-woo microbiome discussion out there that misses the really obvious basics of how the microbiome comes to exist and thrive: What you eat is what the microbiome eats, so changing what you eat will change the composition of bacteria that thrive. People who prefer chocolate are correlated with people who prefer sweet diets. High sugar intake is proven to alter the microbiome.

mrtesthahtoday at 3:33 PM

It makes sense for chocolate given that cocoa flavanols are prebiotic fiber for GABA-secreting bacteria which of course affects the parasympathetic nervous system.

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