> There can be vaccines without being approved for use in said countries.

Unfortunately, the hotbed being Africa makes the situation much worse given historical events - the entire continent has a dark history regarding colonial and modern abuses of power for medical "experiments" [1], and the entire topic resurfaced during the early Covid era [2].

[1] https://en.wikipedia.org/wiki/Medical_experimentation_in_Afr...

[2] https://www.aljazeera.com/opinions/2020/4/8/medical-colonial...