I think you missed my point. The distinction I made in terminology was on purpose: I used "joy" to describe the inherent motivation for trying to accomplish something, and "bliss" for the state some may try to reach by using drugs.
And I also made a distinction between knowledge and meaning, which you sort of seem to imply is a universally shared value, while I seriously doubt that is the case. There are many ways to derive meaning from existence that do not involve amassing knowledge - even just passively profiting off of the knowledge of others, but taking no curiosity in that at all.
And as you pointed out, I carefully phrased impacting the trajectory of humanity to avoid implying any moral judgement. People have many reasons for wanting to leave something behind that outlasts them, which may be good or bad or anything in between.
Obviously you'd want to name "joy" as a separate thing, to propose it as the thing we're motivated to do, but the problem is that you didn't describe it. So now I'm at: the thing we're motivated to do is the thing we're motivated to do, and it's not whatever I say it is, but apart from that you haven't told me anything about it. Of course I'm open to some pluralism, like it can be a string bag of mixed motivations, but I do think the motivations in our culture all agree with creating knowledge, and become vacuous without that element. What is "gain", "pleasure", etc., without meaning? (I don't know what you mean by meaning. I mean the process of explaining and learning and creating ideas.) Without it those are mechanical processes of the "number go up" type. Yes, I am skeptical that anything of that kind is anybody's deep motivation, though it may be a superficial one.
Why are you trying to avoid morality? That seems like a good way to never find out anything important, since importance is a moral judgement.