FWIW GNOME can be used without systemd, and this is how Guix System does it. I think over time more and more components are depending on systemd, but at the current moment it is still feasible to swap them out for replacements that don't.
Can it still? IIRC Guix still has GNOME 48 while GNOME said they'll be increasing they dependence on systemd after version 49 or 50[1]. I'd be happy if Guix can support future version as this seems like an end game distro for me, and I'm (slowly) looking into moving there but my understanding is I'd need to stay with KDE Plasma in the long-term.
Can it still? IIRC Guix still has GNOME 48 while GNOME said they'll be increasing they dependence on systemd after version 49 or 50[1]. I'd be happy if Guix can support future version as this seems like an end game distro for me, and I'm (slowly) looking into moving there but my understanding is I'd need to stay with KDE Plasma in the long-term.
[1] https://lwn.net/Articles/1025560/