My worst interview was at Uber (their security team).

The screening and technical interviews on site were all fine and dandy. At the end of the onsite interviews I spoke with the director in charge of the team. I asked some general questions like, "What's the team's work-life balance like?"

He chuckled and said something like they work 60+ hour works. I looked at him and said flatly, "Yeah, I'm not doing that."

The HR person called me after the onsites and was completely puzzled. She said she never seen a candidate pass technicals and not get an offer. She suggested sending me to another team (I declined).