Star Wars LEGO seems to be the worst. I went to the Bellevue, WA store a few years ago before Christmas. I have no interest in SW or SW LEGO (I'm much more into the Architecture series).
I was walking around though, and an associate came up to me and pointed out that the Death Star (IIRC) was about to stop being sold so if I wanted one I should grab it... "... and that we have several of it, so if you want allll of them."
I despise scalping, though, but perhaps I should.
I assume they were talking about 75159 right before it retired.
I think that was when Lego speculation was just becoming a bigger thing.
Now, I don't think something like that could retire with stock being on the shelf.
I grabbed Betrayal at Cloud City (75222) from my local Lego Store after it retired because they still had one in stock. I don't think I'll get that lucky again.
Especially with the push for exclusive Gift With Purchase (GWP) sets. It's become slightly ridiculous.
But I'm not a speculator, I'm just a dude who likes assembling plastic bricks.