For vegans, creatine is among the recommended supplements, because the amount that is produced internally is insufficient for most people, so they need some extra amount in food. (The same is true for a few other substances, e.g. choline, taurine, menaquinone.)

I also take some creatine, for this reason.

I've heard others say it helps with mood, energy, depression, etc. and if that's the case for some people then great. I don't notice it myself but that's just me. Not everyone has the same body chemistry.

I also have MTHFR gene mutations and sleep issues.

What exactly helped you?

That’s a pretty amazing acronym if real