So in general, I'd say there's maybe 1-2 spoilers, but nothing major. If you want truly 0 spoilage, I wouldn't read it, but if you can tolerate some very minor stuff, you're likely safe.

If you're on page 600 though, there's no spoilers.

Edit: and yes, DFW presaged a lot with this book! Especially around how entertainment has evolved and the negative impact it has. The 'doom scroll' feature is literally called 'infinite scroll' in the software industry. Scary stuff :-/