A few points that come to mind:

* Most applications run on the web nowadays. With TypeScript, you can write both the front end and the back end. * TypeScript shares many syntactic-sugar ideas with Python, but it is also statically typed. Whether that is good or bad is a hot topic, but it gives you a lot of confidence through compile-time checks. * Running Node for system tasks is as easy as running the Python interpreter. However, Python is still slightly ahead there.