One of my favorite games, and I recommend it to anyone who loves a good existential sci-fi horror. If you are not comfortable with stealth games, it also has a "Safe Mode" where enemies aren't a threat to you if you just want to experience the story.
Spoiler warning for those that havent played--
I forget the details exactly, but one scene stuck with me. It was a screen in one of the labs, where an experiment was running over and over. It was an uploaded consciousness of one of the test subjects, stuck in an interview room. He kept realizing he was trapped in a simulation and would start panicking. The computer would reboot him, trying another sequence to get him to not realize he was an AI. I think you as the player are given the option to turn him off forever, iirc.
There's definitely a short story in Accelerando about this same topic.