I went fro regular keyboard to happy user of (slightly modified) Glorious Engrammer here.

I use qwerty and I'm really not a fast typist, but the "primitives" and thought put on this layout, from home row mods timings, pinch movements, mouse layer, symbol layer etc really helped me to stay comfortable keeping the hands on the keys with less finger movement and less overreaching to the mouse, which really was what was harming my wrist.

The keyboard in itself is great and all, being split and easy to mount creatively also helps for ergonomics, but to me it's half the battle. In fact at the begging, with default and using a mouse in the middle of both halves was hurting my hand even more.