This is strange to me, did you really ask like this and which model did you use?

I just tried your no. 1 and 3 verbatim and Opus gave fine answers; no. 6 I've done in the past with no issues. The other ones we can't really replicate without more details, but based on my experience with Opus I don't see what the issue would be.

The reason I'm really surprised by this is I do a lot of biology prompts and the guardrails used to be quite problematic up until some time late last year. Many legitimate prompts would trigger its biosafety filters.

But I haven't seen such filters trigger at all anymore in more than half a year.