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seethishattoday at 12:49 PM3 repliesview on HN

The newer synthetic nicotine pouches (Zyn, On, Velo) are everywhere in the USA and are being used by kids as young as 13. They are ruining the gut health of an entire generation of kids.

Edit: Both boys and girls are dependent on these things now and they seem socially acceptable (no smoke, no spit, just swallow the chemical nicotine). Get ready for a huge wave of GI problems due to this.


Replies

ipsento606today at 1:24 PM

Source for the claim that nicotine use "ruins" gut health?

My understanding is that the relationship between nicotine and gut health (indeed, overall health) is much more complex and nuanced than that. I know that nicotine has a positive effect on ulcerative colitis symptoms for many sufferers.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8895249/#s4

A quote:

Of all the diseases summarized here concerning systemic inflammation, especially in sepsis and endotoxemia, nicotine exerted the most pharmaceutical effect and significantly improved the survival. Next, nicotine is also a potential candidate for treating ulcerative colitis, rheumatoid arthritis, osteoarthritis, multiple sclerosis, and myocarditis; the in vivo data provided a much better foundation. For local inflammation, the nicotine administration route may be more important to avoid its accumulation in other healthy organs—for example, the effect of nicotine on arthritis will be more pronounced when nicotine is directly injected into the focus of infection. Perhaps that is why, in the early years, tobacco was used to treat enteritis as enemas (4). It is evident that nicotine has a significant pro-inflammatory effect on periodontitis. However, the latest research also found that nicotine positively affects periodontitis at a lower dosage. In this regard, we consider that the effect of nicotine on periodontitis is mainly due to the influence of inevitable and original oral microbes. At present, most studies focus on the cellular level, and in vivo studies may be limited due to the difficulty of model construction. Therefore, we recommend that individuals with poor oral hygiene avoid excessive direct exposure to nicotine for oral diseases.

embedding-shapetoday at 1:10 PM

Is your problem with them that they're synthetic, or that it's nicotine? Pouched tobacco like that been used for decades in some places in the world, or even without pouches, just making your own ball and sticking the tobacco under your lip. I'm not sure these countries have a higher rate of GI/gut problems than other places, which kind of would invalidate your entire argument here.

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wossabtoday at 12:55 PM

And teeth. This stuff will do nasty things to your gums. And receded gums never recover.

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