I think author meant he vibe coded some deterministic system. Maybe comparing the whole genome to a healthy one, and pointing out all diffs?

> I’m skeptical that general purpose LLMs are a good fit for a very specialized medical analysis task

If they can save more lives without harming other lives I would gladly take it during the analysis. Even saving 1% more lives is an amazing achievement!

Does it say anywhere that he’s using general purpose models for the analysis? Fine tuning open weight models is generally available for pretty minimal cost, I’d say his reference to vibe coding is how he is building the software not how the software functions.

General models are very cheap to get started with though. So even if they are less than ideal, you can use them to get a company going and then make something more efficient.