I genuinely can't use Fable. I'm a medical physicist. I use the word nuclear a lot. Opus is fine (well, 99% of the time - I've certainly hit the CBRN filters a few times and even been invited to email anthropic about the false positives).

Fable has literally refused to work on any of my problems (even those about fluid dynamics!) and just tells me that I'm violating anthropic's AUP. I've reached out to their support and don't expect to hear anything sensible back. One thing I do look forward to though is OpenAI offering an equivalent model but with less safeguards...