It doesn't even have to impact readability.
See for example
https://github.com/MayaPosch/NymphRPC/blob/master/doc/nymphr...
There's an int8 in the middle of int32s knocking everything out of alignment. And it doesn't need to be because flags is int32 and only uses 4 bits.
Changing that doesn't have to impact readability. Makes it easier to process, makes a struct representation more compact.