I have a couple like that in my mini rack. The problem is the power supply: these take 65W, so I figured I could get a quality 140W charger and power them both, but it turns out that things like "unplugging something else" would kill their power. I had to spend a lot more on a StarTech charger to get the performance I needed

The issue is that a USB charger is not a USB power supply. A charger does its best, but makes no guarantee of constant power delivery or duty cycle. The power supply absolutely must provide its rated output at 100% duty cycle.

A lot of SFF PCs already come with a power brick. Just with a 12V barrel jack instead of a USB-C port. Compared to that design you really wouldn't safe much space. Though I admit that USB-C would be convenient. Maybe with a tiny battery

> And if USB-C could somehow provide a range of voltages to the motherboard, SFFPC's could be downsized even more

You reeeeeeally don't want to do that. Cable inductance is a big deal, among other issues. You want the main DC-DC regulators on the board, usually right at the load, for the main loads. Most of the PSU bulk is for dealing with mains itself: handling 50/60Hz or mains isolation is just physically large. Getting in secondary 20V DC (or so) from a single connector and then regulating it down on board is pretty much the ideal solution.

(I can't even begin to comprehend the horrors of a USB-PD negotiation involving multiple voltages. It's already the worst standard I've ever had to deal with.* Don't make it worse!)

(* Not hyperbole, it is truly, truly awful. At least things like 60601 are bad because, you know, they're covering lots of stuff like lifesaving medical devices. USB-PD is... holy hell, it is just bad.)

There are some SFF PCs that can take USB-C power.

Lenovo have some,but sometimes require adapter cards. And a few of the Chinese N150 units will take PD power

It's great for hot swapping and more portable than a laptop.