5 grams isn't a high dose though, I'm not sure why it's described as such. Shops sell doses starting at 15g, although they recommend newbies take only half of that.

Example of a shop which describes 5g as a "light dose": https://www.sirius.nl/atlantis/

The Johns Hopkins studies have been administering high doses for 20+ years now. The difference is that they use synthesized psilocybin instead of mushrooms (which makes the dosing more consistent since potency can vary a lot across strains and individual mushrooms).

It's not just 5 grams of some random cubensis, it's 5 grams of the enigma strain, which is ridiculously potent.

Yeah this story was on HN before a few weeks ago and I raised similar - it’s nuts to give that to someone who probably doesn’t have the mental state to be able to comprehend what is going on. Don’t understand how it is possibly ethical to do.

Especially with the effects being temporary - can you imagine how awful it must be to regain lucidity outside of your control and then lose it again for the sake of an experiment like this? Awful experiment.

While it’s a fairly good sized dose, it’s not one that would typically produce a nightmare trip scenario.

As far as ethics go, I would absolutely sign a document that gives the right for experimentation in the event I become incapacitated to some degree.