FWIW, the various Rust react-like libraries (Yew, Dioxus, Leptos) are all reasonably fast for many/most applications. Even if the DOM goes through a JS interpreted layer.
Something akin to raw sockets over a host interface (or WSS bridge) could be cool... similar for sandboxed FS access, which browsers are starting to improve upon.
Yes, fully WASI/WASM would be nicer than some of the JS glue... but it's still useful all the same.