alt Hacker NewsI use Qiling [0] (built on top of Unicorn) sometimes for this kind of things (it can take application snapshots, that you can restore; and you can also use something similar to x86/x86-64 memory hardware breakpoints too). Might fit what you want, although it can sometimes be in a pain in the rear to set up...
Sweet, thanks. It doesn't seem to be exactly what I'm looking for, in that it simulates (replaces) the OS instead of hosting it, but it's still interesting.