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arcticbulltoday at 4:53 AM3 repliesview on HN

You’re dealing with populations here. Literally the odds of a positive being false would be over 90%. Much higher in the more rare conditions. I’m not exaggerating. That means every almost every follow up you do is a waste of time, money and limited resources, denying care to those who need it. Including you when you actually do need it. It also exposes you to the risks of unnecessary follow-ups like infection. Your expected outcome is worse this way.

The chance a positive is real is so low you may as well just point to a body part and get it biopsied.

A positive from this kind of test is statistically meaningless.


Replies

munificenttoday at 5:14 AM

It's scary in both directions.

If you let it give out tons of false positives, then patients are trained to ignore it when it cries wolf.

If you dial it back so that it gives out fewer positives, then now it starts giving out false negatives and not helping sick people.

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hereme888today at 12:39 PM

You're right. I wrote a bad response at midnight. I meant to say something more narrow and specific: genomic assessments and new biomarker tests will become affordable and add information.

For example, single nucleotide polymorphisms. This way doctors spend less time guessing which medication is likely to work best for you when there are many options available.

charcircuittoday at 7:46 AM

That doesn't sound like a useful test then. Instead use tests with fewer false positives.