It might be fine for just avoiding clutter, but be warned that distrobox defaults to very weak separation between container and host (e.g. default mounting your real home into the container). Good organizational tool, bad sandbox. (This is not a fault, just a matter of what the tool is optimized to help you do.)
I like that as a feature because I can use it like a normal root system. I have a pretty easy time seeing what goes in my home folder. It isn't esoteric to explore like system folders. If I had something I needed to keep private from Distrobox I could put it in my SD Card since it isn't mounted in the home folder on SteamOS and is in /run/media. You could also install QEMU in Distrobox or the virt-manager flatpak for a full sandbox.