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epistasisyesterday at 10:15 PM8 repliesview on HN

How is discussion on HN different from the leadership levels at FDA?

Very different. Decisions with enormous health implications, enormous financial implications, are made at FDA.

At HN, most people are here to learn, here to understand more.

Vinay Prasad is a fraud, completely unfit for the leadership role he was placed into, making baffling and arbitrary decisions on his own, overturning those with far more experience, knowledge and expertise.

If a HN comment gets things wrong, a few people might be misinformed, if they are credulous enough to not double check things.

When the FDA makes decisions like they have been making, thousands to millions of peoples' lives are worse off, and billions in capital is wasted.

Discussion forums of all sorts are incredibly valuable, even when they get things wrong. I have lots of complaints about the overhyping of, say, CRISPR, especially on HN, but whatever, it's a far far higher signal-to-noise than a random person I meet around town. Mention you work on drug development for big pharma to the random person and they think you're evil, at least HN is less likely to have that basic misconception.


Replies

JumpCrisscrossyesterday at 10:30 PM

> Vinay Prasad is a fraud

What’s with him being allowed to continue to practice at the University of California [1]?

[1] https://vinayakkprasad.com/

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8noteyesterday at 11:29 PM

> Mention you work on drug development for big pharma to the random person and they think you're evil

this is how Martin Shkreli described his work of identifying drug patents to buy that he could jack up the prices on. If that's the extent of the description you gave, I think random people would be right to first think you are doing something evil

Zhenyayesterday at 10:26 PM

I’m curious why you claim he’s a fraud, I just learned about him from this thread.

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DANmodeyesterday at 10:46 PM

People making decisions at the FDA should also be actively learning and understanding more all the time.

That should be their primary objective.

mmoossyesterday at 10:45 PM

> Decisions with enormous health implications, enormous financial implications, are made at FDA.

Yes, I started writing that and didn't finish the sentence (see my edit near the end of the GP).

But I don't let HN off the hook: The attitude I described in the GP represents and perpetrates the same outlook that politically supports or tolerates this behavior from the FDA. HN users generally legitimize that approach rather than discrediting it.

> Mention you work on drug development for big pharma to the random person and they think you're evil

I think that's paranoid: The random person won't know what that means. Few who know will also know or care about the social implications. Of those who do, only some will be knee-jerk critical of big pharma, and fewer still of research rather than the business side. It's also a victim perspective: Big Pharma has enormous power; punching up at power by questioning, criticizing, and being skeptical (or even cynical) is not at all the same thing as punching down at the vulnerable. If someone wants the power and resources and salary of Big Pharma, benefitting from its enormous power, the pushback and reputation impact comes with it (though the latter is usually positive - great resume material and credibility).

naturalmovementyesterday at 10:25 PM

Imagine being able to shut down discussion at the FDA because a few anonymous randos pushed a "flag" button when they saw something they disagreed with.

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bediger4000yesterday at 11:55 PM

At HN, most people are here to learn, here to understand more.

There's a substantial "learn and understand" cohort, but there are other factions. At the start of the pandemic, there were 2 posters explicitly here to proselytize Trump style conservatism. I'm reasonably certain there was an anti-vaxx voting ring 2020-22, and I suspect there's remnant Elon fanboy and MAGA coordinated voting.

I'd love to be proved wrong on these things.