That wouldn't have worked, the point was to pack data in memory. Even on 64kb computers, MS-DOS 1.x loaded .COM files at the bottom of available memory and allowed using the "familiar" CALL 5 interface even if the program was not loaded at physical address 0x100 (which is part of the interrupt table on x86). MS-DOS 2.x augmented that with TSR (terminate and stay resident) programs that could relocate themselves to use the minimal amount of memory at 16-byte offsets.

The 68000 was a complete break so it opted for relocatable code (which also needed more registers, and in fact the 68k had 16 instead of 8).