We had a PC that came properly-licensed with that edition of Windows (with the matching sticker and everything), and it didn't work out as a desktop machine for the intended user. It's been a year or two and some details are lost, but IIRC there were issues with some Intuit program or other.
It was probably something that could have been worked around, but workarounds tend to pile up and become difficult to track. I avoided the problem by putting a more-pedestrian version of Windows 10 on it instead.
Some "bad" coded programs have hard-coded version check and check for the OS name instead of build number, if they forgot LTSC (and server and education) the software will refuse to run on these version. Some reg edits can fix this but its a pointless hassle, there is no need to use LTSC today there are no more annoying updates and unwanted features being added. I have a windows 10 pro machine here running since 3 month 24/7.