But those changes don’t stick if the drug is discontinued.
Is the drug at risk of being discontinued? If so, then can that risk be quantified in any way?
(For comparison: Countless scores of diets are discontinued daily.)
AIDS drugs also don't stick. So?
Diets also don't stick when you discontinue them.
It would be an incredible advancement if we figured out a reliable and replicatable way to just eat less food, but until then I think a drug that makes you do that is pretty decent.