logoalt Hacker News

nostreboredtoday at 6:05 PM6 repliesview on HN

Daily allergy tablets are associated with huge increases in early onset Alzheimer’s. Glad you found something that works, but might be good to get some of the allergen injections :)


Replies

linsomniactoday at 8:54 PM

That seems to be only for first generation, drowsy-making, tablets. Second gen formulas don't cross over the blood/brain barrier.

https://www.myalzteam.com/resources/zyrtec-and-alzheimers-me...

There IS one year-old finding that suddenly stopping Zyrtec after daily 3-month use may lead to nasty itching, and if that happens you can re-start and then taper off. https://www.fda.gov/drugs/drug-safety-communications/fda-req...

cenamustoday at 6:14 PM

Where are getting that from?

All I can find is about 1st gen antihistamines (i.e. Benadryl, which I doubt many people take daily, because of the drowsiness).

Even for those, evidence seems to be mixed at best. "Huge increases" seems like hyperbole.

fuomag9today at 7:31 PM

Only first gen, 2nd gen does not have this issue anymore or it’s greatly reduced

meindnochtoday at 6:23 PM

Misinformation.

Only first-generation antihistamines with anticholinergic effects are associated with cognitive decline in elderly patients.

show 1 reply
tnchrtoday at 6:13 PM

I believe it depends on which ones, the older gen or certain classes of antihistamines

darkwatertoday at 6:22 PM

Wait, what?? Now I'm getting in panic mode because I do take regularly anti-hystaminic tablets/pills (the newer ones, based on ebastine because they don't make me feel sleepy)

show 1 reply