What would be different about a bike designed for Africa than one designed for anywhere else? What parts that require specialized tools should be redesigned to use standard tools?
Some parts of Africa are similar to elsewhere, but obvious things would be parts that can deal with either extreme dryness or humidity (both problems in different parts of the continent), good suspension (for areas with bad roads), bright colours (for visibility on shared roads), integration of bike locks and easy self-repair (for people in more remote areas).
Well I'm not African so I don't know.
I'm thinking that in the west we either have very cheap bikes that aren't really designed for long term use, and more expensive bikes tend to use fancier parts.
Off the top of my head. Steel frame, can be repaired / modified with any old welder. Designed so it can be taken apart with the minimum of generic tools. Standard bearings, brake blocks etc (probably brake blocks that you can shove some piece of old tyre in).
Front forks and the crank require special tools to remove. I assume the free wheel assembly would be the same. I don't know if it would be possible to modify these to be serviceable with basic tools, the point is an African could probably work out how to fix a bike, the issue would be affording tools and spares, and availability of those tools and spares.
https://www.buffalobicycle.com/storage/documents/Buffalo_com...
The buffalo bike is one that was specifically made for developing nations and the project prioritizes local assembly and repair, while the bike is designed to sacrifice weight and aerodynamics, instead offering heavier-duty parts like thicker rims, puncture-proof tires, high-capacity racks, etc. This bike has two chains to reduce the likelihood of a critical failure and an internal coaster brake hub which is more robust to the elements.
Your average low-cost bike isn't intended to be used in environments with rough terrain and high contaminant concentrations without regular maintenance, and especially older bikes with things like cup and cone bearings which are more susceptible to dirt getting in, thinner tires which puncture more easily, and nonstandard bits and pieces like derailleur hangers which predate the UDH standard.