In my fairly extensive experience, non-profit organizations are not just full of and run by grossly incompetent people, but deeply arrogant and/or deluded ones as well. I have NEVER found an organization that has a genuine desire to seek truth, efficacy etc. They often go with whatever their first (inevitably insufficient) idea was, and not only reject all criticism but respond with indignity, etc...

There's no meaningful/competent oversight. It's all just about feels and optics. And thus no real progress has or will be made.

Anyway, yes, I agree that competent and genuine people (who are extremely rare) ought to try to make a meaningful impact in the world. But there's generally more money in something else.

(one rare exception that comes to mind, though i haven't visited them, is The Ocean Cleanup project. They seem to be experimenting and succeeding towards the worthwhile goal of making effective engineering interventions for cleaning up waterways and oceans)