I switched from a giant docker compose file to podman quadlets on my homelab. IIRC it look me a little while to translate the first couple of services because there wasn't (at the time, at least) as much documentation/examples of quadlets as compose files, but after that it was a piece of cake. I highly recommend them.

The only issue I have is validation, there isn't a convenient built-in command to validate quadlet files and systemd doesn't warn you if any fail to generate. You either have to do a --dry-run first (and probably alias the full command to something reasonable) or check the journal for errors.