Guix uses mrustc for bootstrapping Rust, as required for compiler packages; it's a really impressive project and has worked well in that role for some time. This new project is interesting for other reasons though, because mrustc is targeted at the de fact "subset" of Rust in use by rustc at any given time. This looks like it could have broader applications, like compiling Rust programs for platforms not supported by LLVM. If it really targets ANSI C (C89 or so), that's potentially many more platforms than are possible with ordinary rustc

More on the Rust bootstrapping process (2018): https://guix.gnu.org/blog/2018/bootstrapping-rust/