> What happens when the low-hanging fruit is gone?
Depends on why it's gone? For example, before the shocker of Facebook buying Oculus, there was an active community of side-gig businesses selling kits around VR, large touch panels, haptics, and such. What couldn't exist, was scaling that beyond hobby kits. No VARs, no integrators or assemblers, no OEMs, no contract or bespoke manufacturing, no searching for viable niche products. Because "it's merely a kit" was the only way the US patent system allowed the stuff to exist at all as a business. The gap between what you could make, and what you're allowed to sell, is large. Even now, we can't reasonably search for those niche market fits, because such scales are beneath the notice of big patent-holding companies. So absent FRAND reform or some such ("you're required to let me use it and pay you"), no fruit for you.
CA lacking non-competes, "Stealing IP!", grew software fruit in CA. But the US has lacked the growing conditions for Shenzhen fruit. So, what happens when the low-hanging fruit is gone, from the US? Fruit is grown, and enjoyed, elsewhere.